Job ID

REQ-10025724

Oct 15, 2024

Switzerland

Summary

Location: Basel, Switzerland
Full time, onsite, #LI-onsite

One purpose- to reimagine medicine! Novartis Biomedical Research is the innovation engine of Novartis. We collaborate across scientific and organizational boundaries, with a focus on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.

Discovery Sciences (DSc) Basel is offering an exciting opportunity for an exceptional scientist with a dual experimental and computational background to join our efforts to discover novel therapeutics and drug targets. We are seeking a highly motivated and innovative scientist with a vision to combine data and lab work for drug discovery impact. The selected candidate will join a lively scientific community, working within an integrated team combining expert wet and dry approaches with the massive amount of biomedical data for disease target discovery and validation.

About the Role

The DSc department encompasses the full spectrum of advanced capabilities and cutting-edge technologies needed to succeed in a state-of-the-art and collaborative drug discovery environment.

Your responsibilities will include but are not limited to:

• Design and implement a scalable genomics approach for functionalization of genetic variants, deconvolving disease circuitry and target validation.

• Perform research as a contributing bench scientist combining wet and dry approaches, whilst engaging in an interdisciplinary and collaborative matrix environment throughout.

• Develop relationships with external stakeholders and collaborators, within DSc and across diverse Disease Areas, and represent Novartis values of transparency, integrity, courage, innovation, quality and collaboration.

What you'll bring to the role:

Minimum requirements

• Ph.D. in biology, biochemistry, genetics, genomics or related fields, with ideally a minimum 2-4 years Postdoctoral and/or industry experience

• Strong expertise in gene editing, mammalian cell culture, in vitro disease models and molecular biology.

• Proficiency in genomics screens (pooled and/or arrayed) and single cell techniques.

• Solid bioinformatic skills (Unix, R and/or Python), including experience analyzing and visualizing single cell RNA-seq data and/or genomics screens.

• An exceptional record of accomplishments that demonstrate innovation, productivity and capability to work in a constantly evolving, collaborative and interdisciplinary research structure.

• Demonstrated ability to hands-on contribute to projects that answer key questions in areas involving target identification, cell signaling pathway dissection and/or disease biology understanding.

Comfortable with working at the bench in a wet/dry lab environment

• Exceptional collaboration, communication and problem-solving skills, learning agility, and an interest in engaging with peers for the design and implementation of new idea

Desired requirements

• Hands-on experience with CROP-/Perturb-seq design, execution and analysis.

• Understanding of statistical human genetics and experience with functionalization of disease-associated variation.

• Experience with complex cellular systems, including iPS-derived cultures.

• Understanding of AI Foundation Model applications to target discovery.

*Restrictions on working flexibility may apply to this position and can be discussed at interview as required

Accessibility and accommodation
Novartis is committed to working with and providing reasonable accommodation to all individuals. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the recruitment process, or in order to receive more detailed information about the essential functions of a position, please send an e-mail to inclusion.switzerland@novartis.com and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients- lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture

Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network(link is external)

Benefits and Rewards: Read our handbook to learn about all the ways we-ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Division

Biomedical Research

Business Unit

Pharma Research

Location

Switzerland

Site

Basel (City)

Company / Legal Entity

C028 (FCRS = CH028) Novartis Pharma AG

Functional Area

Research & Development

Job Type

Full time

Employment Type

Regular

Shift Work

No

Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.